Drugs that commonly cause allergic skin reactions
(as reported by the Boston Collaborative Drug Surveilance Program)
| Drugs | Reactions per 1,000 people Tested |
| Penicillins |
|
| Ampicillin | 52 |
| Semisynthetic Penicillins (cabenicillin, cloxacillin, sodium monohydrate, dicloxacillin, methicillin, nafcillin, oxacillin) | 36 |
| Penicillin G | 16 |
| Gentamicin sulfate | 16 |
| Cephalosporins (cephalexin monohydrate, cephaloglycine dihydrate, cephaloridine, cephalothin sodium) | 13 |
| Quinidine | 12 |
| Dipyrone | 11 |
| Mercurial diuretics (meralluride, mercaptomerin sodium) | 9.5 |
| Heparin | 7.7 |
| Trimethobenzamide hydrochloride | 6.6 |
| Nitrazepam | 6.3 |
| Barbiturates (amobarbital, barbital, butabarbital, butethal, mephobarbital, pentobarbital, phenobarbital, secorbarbital) |
4.7 |
| Chlordiazepoxide | 4.2 |
| Diazepam (Valium) | 3.8 |
| Propoxyphene | 3.4 |
| Isoniazid | 3.0 |
| Guaifenesin (Guaifenesin and theophylline) | 2.9 |
| Chlorothiazide | 2.8 |
| Furosemide | 2.6 |
| Isophane insulin | 1.3 |
| Phenytoin | 1.1 |
| phytonadione | 0.9 |
| Flurazepam hydrochloride | 0.5 |
| Chloral hydrate | 0.2 |
Source: Adapted from “Rates of Cutaneous Reactions to Drugs,” by Kenneth A. Arndt and Hershel Jick, Journal of the American Medical Association, March 1, 1976.
Analgesics (Pain Relievers) That Cross React with Aspirin
| Usually Cross React | Sometimes Cross React |
| Fenoprofen Fluenamate Ibuprofen Indomethacin Mefanamate Phenylbutazone | Naproxen Sulindac Tolmetin |
Source: “Aspirin Intolerance in Asthmatics: Who Is Susceptible and Why?” Modern Medicine, January 15-30, 1979, p.65.
Drugs Containing Tartrazine (FD&C Yellow No. 5)
| Altromid-S (capsules) Aminophylline Anusol (suppositories) Ascorbic acid Bactrim Cepacol (mouthwash) Colchicine Coricidin Decadron Dimetane Donnagel Dulcorax Ferrous sulfate (tablets) Hydrochlorothiazide Ilosone Intal (in gelatin capsules) Keflex | Lanoxin Marax Methotrexate Mysoline (suspension) Novahistine Ortho-Novum Phenergan (syrup) Phenobarbital Potassium chloride Prednisolone Premarin Seconal Tedral Triaminic (expectorant DH) Tuss-Ornade (liquid) Xylocaine (viscous) |
Source: “Aspirin Induced Asthma in Children,” by Y. Tan and C. Collins-Williams, Annals of Allergy, January, 1982, p.4.
Common Drugs Containing Aspirin (Acetylsalicylic Acid)
| Alka-Seltzer Anacin APC A.S.A. Compound Ascriptin | Bufferin Coricidin Empirin Compound Exedrin Fiorinal | Percodan Sine Aid Trigesic Vanquish |