Allergy Drugs and Their Side Effects

Types of Drugs Generic or Chemical Names Trade Names Types of Allergy Treated Most Common Side Effect
Antihistamines akylamine* (most commonly prescribed) Actidil, Dimetane Extentabs, Polaramine, Polaramine Repetabs, Triten, Triten Tab-In Hives (urticaria), contact dermatitis, eczema, hay fever (allergic rhinitis), Drowsiness, nausea, abdominal discomfort, dry mouth
athanolamine Ambodryl, Benadryl, Clistin, Decapryn, Diafen, Dramamine, Hispril, SK-Diphenhydramine, Tavist gastrointestinal allergy
ethylenediamine* Nivasal, PBZ, PBZ-SR
phenothiazines Phenergan, Tacaryl, Temaril
piperazines Bonine, Merezine
miscellneous Atarax, Optimime, Periactin, Vistaril
Bischromones cromolyn sodium Intal, Lomudal Asthma (allergic and exercise induced), gastrointestinal allergy Throat irritation, hoarseness, coughing, wheezing. Safety during pregnancy not yet determined
Bronchodilators 1. Adrenergic agonists Asthma, hives (occasionally) Fear, anxiety, tenseness, restlessness, headache, weakness, dizziness, pallor, accentuated heartbeat, nausea, insomnia, tremor

albuterol

Proventil, Ventolin

pehedrine

Ephedrine USP

epinephrine

Adrenalin Chloride, Bronkaid Mist, Bronkophrine, Primatene M, Primatene Mist, Primatene P, Sus-Phrine

isoetharine

Bronkometer, Bronkosol

isoproterenol

Aerolone, Duo-Medihaler, Isuprel, Norisodrine

metaproterenol

Aluprent, Metaprel

protokylol

Ventaire

terbutaline

Brethine Bricanyl
2. Methylxanthines Asthma Irritation of stomach or intestines, nausea, abdominal cramps, heartburn, exacerbation of ulcers, temporary sleeplessness, nervousness

aminophylline

Aminophyllin, Aminophylline, Phyllocontin

oxtriphylline

Choledyl

theophylline

Bronkodyl, Bronkodyl S-R
Corticosteroids 1. Aerosol Hay fever, nasal polyps, asthma Dry mouth, hoarseness, fungal infections of mouth and throat

beclomethasone dipropionate

Beclovent Rinse mouth thoroughly with water after each use

dexamethasone

Decadron Phospate Respihaler, Decadron Phospate, Turbinaire
2. Systemic All allergies, especially acute, chronic asthma; acute hives; drug reactions Water retention, weight gain, susceptibility to bruising, stretch marks, more body hair, insomnia, uneasiness, leg cramps, "moon face." (most minor side effects likely more long term use at high doses).
Suppression of adrenal hormones

betamethasone

Celestone

cortisone

Cortisone acetate

dexamathesone

Decadron

hydrocortisone

Many trade names

methylprednisolone

Medrol, Methylprednisolone

paramethasone

Haldrone

triamcinolone

Aristocort
3. Topical (creams, gels, ointments) Variety of trade names Rashes (especially eczema and contact dermatitis) Burning sensations, irritation, itching, dryness, inflammation of hair follicles, acne, loss of pigmentation, thinning of skin, stretch marks, tendency of bruise easily, skin ulcers (Side effects depend on potency, concentration and duration of use)
Contact dermatitis can result when cream, gel or ointment contains preservatives
betamethasone
desonide
desoximetasone
dexamathasone
flumethasone
fluocinolone acetonide
flurandrenolide
halcinonide
hydrocortisone
prednisolone
triamcinolone acetonide
Decongestants naphazoline Privine Hay fever, gastrointestinal allergy Nervousness, dizziness, nausea, rapid heartbeat
Do not use nasal decongestants for more than 5 days. May prolong symptoms
oxymetazoline Afrin
phenylephrine Neo-Synephrine
pseudoephredrine hydrochloride Novafed, Sudafed
tetrahydrozoline Tyzine
zymetazone Otrivin
Expectorants iodides Organidin, Potassium Iodide USP Asthma Nausea, abdominal cramps and diarrhea; unpleasant brassy taste and burning sensation in mouth and throat; sore teeth and gums; increased salivation
quaifenesin Glycotuss, Robitussin, 2/G Asthma none

Source: Adapted from The Allergy Encyclopedia, by Craig T. Norbeck and Raymond G. Slavin (New York: New American Library, 1981). Physicians' Desk Reference (Oradell, N.J. Medical Economics Co. 1982).

* Found in many over the counter remedies for colds, hay fever and headaches.